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Both potassium antimonial tartrate and oltipraz inhibit TGR 18 by a covalent mechanism and were used clinically for schistosomiasis treatment but were discontinued due to unacceptable side effects 28,29

In human colonic epithelial T84 cells, an increase in cAMP-stimulated chloride secretion has been shown to be mediated either by phosphorylation of CFTR [17] or by recruitment of the transporter to the AM [77]

JHU083 has also demonstrated excellent therapeutic efficacy in preclinical models of IDH-mutant gliomas and significantly reduces mTOR signaling (Yamashita et al., 2021)